Effect of Group A Streptococcus Preparation combined with mitomycin and lentinan combined with mitomy-cin in the treatment of malignant pleural effusion through intrapleural catheter
10.3760/cma.j.issn.1008-6706.2016.13.015
- VernacularTitle:溶链菌制剂联合丝裂霉素与香菇多糖联合丝裂霉素胸腔灌注治疗恶性胸腔积液的疗效研究
- Author:
Yihui ZHANG
;
Jiawei REN
;
Qingwen ZHANG
;
Ke YANG
- Publication Type:Journal Article
- Keywords:
Malignant pleural effusion;
Group A Streptococcus Preparation;
Lentinan;
Mitomycin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(13):1975-1977,1978
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect and side effects of Group A Streptococcus Preparation(Sapylin)com-bined with mitomycin and lentinan combined with mitomycin in treating malignant pleural effusion through intrapleural catheter.Methods 70 malignant pleural effusion patients were selected in this study.All the patients were randomly divided into Sapylin group and lentinan group.One case with penicillin positive of the Sapylin group was adjusted to enter the lentinan group.After drainage of pleural effusion,the patients were divided into Sapylin group (34 patients) and lentinan group (36 patients).For the Sapylin group,Sapylin was prior injected and mitomycin was posterior injected.For the lentinan group,lentinan was prior injected and mitomycin was posterior injected.The side effects and clinical effect were observed and reported.Results The effective rate of Sapylin group was 85.3%,whereas 83.3%of lentinan group.There was no significant difference between the two groups(χ2 =0.051,P =0.822).Both groups had the following minor side effects:chest pain,fever,vomit and decreased white blood cells.No liver or renal injuries were reported.Conclusion The clinical outcomes of Sapylin combined with mitomycin and lentinan combined with mitomycin are both positive,in addition,the side effects are minor.
