Correlation of serum Hcy,UA levels and Parkinson's disease

VernacularTitle:血清同型半胱氨酸、尿酸水平与帕金森病的相关性分析
Author: Zhongming GAO ; Haibo JIANG ; Jiqing HE ; Xiaodong LU ; Xiaochuan WANG
Publication Type:Journal Article
Keywords: Homocysteine; Uric acid; Parkinson's disease
From: Chinese Journal of Primary Medicine and Pharmacy 2016;23(13):1998-2001,2002
CountryChina
Language:Chinese
Abstract: Objective To study the variation of serum Hcy and UA of Parkinson's disease.Methods 46 pa-tients with Parkinson's disease in our hospital from April 2015 to March 2016 were selected as observation group,and 57 patients with other disease at the same time were selected as control group.The contents of serum Hcy and UA of the two groups were analyzed and compared.Results The contents of serum Hcy and UA of the observation group were (17.82 ±3.12)μmol/L,(321.42 ±79.42)μmol/L.Those of the control group were (10.12 ±3.05)μmol/L, (420.15 ±70.18)μmol/L.The content of serum Hcy of observation group was higher than the control group,the con-tent of serum UA of the observation group was lower than the control group(t =12.608,P <0.01).Hcy content of middle and late patients[(18.86 ±3.12)μmol/L]was higher than early patients[(16.16 ±3.04)μmol/L](t =2.378,P <0.05),serum Hcy level was positively correlated with UPDRS(r =0.462,P =0.037),the differences were significant.Conclusion Changes of serum Hcy and UA levels were related to the occurrence of Parkinson's disease.