The predictive values of HIF-1 and VEGF in early diabetic nephropathy
10.11958/20150092
- VernacularTitle:HIF-1α、VEGF在预测早期糖尿病肾脏病中的价值
- Author:
Qiuyan SONG
;
Ling YU
;
Ruihong DONG
- Publication Type:Journal Article
- Keywords:
diabetic nephropathies;
vascular endothelial growth factors;
hypoxia-inducible factor 1,alpha subunit;
glo-merular filtration rate;
urinary albumin excretion
- From:
Tianjin Medical Journal
2016;44(6):752-754,755
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive values of hypoxia-induced factor(HIF)- 1α and vascular endothelial growth factor (VEGF) in patients with type 2 diabetic kidney disease, and its relationship between HIF-1α, VEGF and glomerular filtration rate (eGFR). Methods Seventy-six patients with type 2 diabetic kidney disease were divided into two groups:DKD1 group [eGFR>90 mL/(min·1.73 m2),n=48] and DKD2 group [60 mL/(min·1.73 m2)0.05). Serum levels of HIF-1α and VEGF were significantly higher in DKD2 group than those of DKD1 group (P<0.05). There were negative correlation between VEGF and HIF-1αlevels with eGFR level (r=-0.59, P<0.01;r=-0.55, P<0.01). ROC curve showed that serum VEGF and HIF-1αlevels were above the opportunity diagonal. The diagnostic sensitivities of HIF-1 to DKD1 and DKD2 were 92.1%and 87.4%. The diagnostic specificities of HIF-1 to DKD1 and DKD2 were 91.7%and 85.4%. The diagnostic sensitivities of VEGF to DKD1 and DKD2 were 96.1%and 86.2%, and specificities were 93.3%and 89.1%. Conclusion Serum levels of VEGF and HIF-1αchange with the severity of diabetic nephropathy are likely to be an early predictor for the progression of diabetic kidney disease.
