Research progress on relationship between microRNA and gastric cancer
10.3969/j.issn.1001-1978.2016.06.004
- VernacularTitle:微小RNA与胃癌关系的研究进展
- Author:
Yudi MAO
;
Xiping DING
;
Hua WANG
- Publication Type:Journal Article
- Keywords:
microRNA;
non-coding RNA;
gastric cancer;
anti-tumor;
tumor marker;
therapeutic target of gastric cancer;
gene regulation
- From:
Chinese Pharmacological Bulletin
2016;32(6):756-759,760
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer has a high incidence and accounts for a notable proportion of global cancer mortality.The pathogenesis of gastric cancer is complex involving multiple genetic and epige-netic alterations factors.In recent years,studies have also dem-onstrated the aberrant regulation of miRNAs in a variety of tumor pathological processes including the gastric cancer through af-fecting cell proliferation,differentiation and apoptosis.miRNA also plays important roles in gastric cancer growing,invasion, metastasis,and drug resistance of gastric cancers,which might become new biomarkers and potential therapeutic targets in the future.This paper summarizes several important miRNAs in-volved in gastric cancer and also discusses their function.
