Research progress of p38 MAPK in painful diabetic peripheral neuropathy
- VernacularTitle:p38MAPK 在痛性糖尿病周围神经病变的研究进展
- Author:
Fangfang LU
;
Juanjuan WANG
;
Quanmin LI
- Publication Type:Journal Article
- Keywords:
p38MAPK;
PDPN;
Diabetes mellitus;
Diabetic painful neuropathy
- From:
Journal of Chinese Physician
2016;(z1):259-261,262
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic peripheral neuropathy is a common complication of diabetes mellitus,can occur in some patients with painful diabetic peripheral neuropathy.The occurrence of PDPN is related to many factors,such as long term severe hyperglycemia and metabolic disorders,deficiency of neurotrophic factors, disorder of microcirculation,increase of oxygen free radicals in oxidative stress and disorder of immune func-tion.Mitogen activated protein kinase (MAPK)is a kind of serine /tyrosine protein kinase ,which can widely expressed in cell,and can be involved in the pathophysiological process of stress,inflammation,cell cycle and apoptosis through increased nuclear transcription factors.P38MAPK signaling pathway is an im-portant branch of the MAPK,this overview focuses on the research progress of p38MAPK signaling pathway in the pathogenesis of PDPN.
