Effects of monocyte CD141 and platelet CD36 on peripheral vascular endothelial function in patients with hypothyroidism
10.3969/j.issn.1006-5725.2016.10.013
- VernacularTitle:CD141与CD36对甲状腺功能减退症患者外周血管内皮功能的影响
- Author:
Yufeng CHEN
;
Wei PAN
;
Meiting QIU
;
Caifen WEI
;
Fangsheng QIN
- Publication Type:Journal Article
- Keywords:
CD141;
CD36;
Hypothyroidism;
Endothelial cells
- From:
The Journal of Practical Medicine
2016;32(10):1595-1597,1598
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of monocyte CD141 and platelet CD36 on peripheral vascular endothelial function (VEF) in patients with hypothyroidism (PWH). Methods The number of mono-cyte CD141and platelet CD36 from 52 patients wtih PWH and 40 healthy persons (control group) was calculated by flow cytometry. VEF was detected in terms of brachial artery flow-mediated dilatation (FMD) using Doppler ultrasonography. The differences of expressions of monocyte CD141 and platelet CD36 were compared between the two groups, so was FMD. The association of monocyte CD141 and platelet CD36 with FMD (%) was analyzed by Pearson analysis. Results Expression of monocyte CD141 (%) was significantly higher in the PWH group than in the control group (21.79 ± 9.45 vs. 18.84 ± 9.64, P < 0.001), so was expression of platelet CD36 (%) (34.26 ± 10.23 vs. 28.65 ± 9.53, P < 0.001). FMD% was lower in the PWH group than in the control group (8.65 ± 1.97 vs. 11.25 ± 2.72, P < 0.001). CD141 was negatively correlated with FMD% (r = -0.657, P < 0.01), so was CD36 (r = -0.557, P < 0.01). Conclusions Both monocyte CD141 and platelet CD36 are significantly higher in the PWH group than in the control group. CD141 and platelet CD36 are negatively related with VEF.
