Relationship between heart-type fatty acid-binding protein and cardiovascular events after thoracic surgery in aged patients
10.3760/cma.j.issn.1008-1372.2016.04.014
- VernacularTitle:心型脂肪酸结合蛋白对老年患者开胸术后心血管事件的预测价值
- Author:
Bin YANG
;
Jian SHI
;
Weimin XIONG
;
Biaotong HUANG
- Publication Type:Journal Article
- Keywords:
Fatty acid-binding proteins/ME;
Thoracotomy/AE;
Cardiovascular diseases/CO/ME
- From:
Journal of Chinese Physician
2016;18(4):536-538,543
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the predictive value of heart-type fatty acid-binding protein (HFABP) in predicting the cardiovascular events after none-cardiac thoracic surgery in aged patients.Methods Sixty eight aged patients were admitted from February 2012 to August 2014 and accepted none-cardiac thoracic surgery.The patients'general information and the incidence of postoperational cardiovascular events were recorded.Serum H-FABP was measured.The receiver operating characteristic (ROC) curve was constructed and the predictive effect of serum H-FABP for prognosis was analyzed.Results Eighteen patients were suffered from postoperative cardiovascular events (PCE).The level of H-FABP after surgery in patients with PCE was higher than that with none-PCE (P ＜ 0.05).The serum concentration of H-FABP after surgery and NT-proBNP before surgery was the independent risk factors for the elderly patients undergoing non-cardiac thoracic surgery.The area under ROC of H-FABP was 0.840 (95％ CI:0.716 ～0.964,P ＜0.01).The sensitivity and specificity of predicting postoperational cardiovascular event with serum concentration of H-FABP ＞5.26μg/L was 77.8％ and 84.0％ (OR 15.944,95％ CI:4.239 ～59.978,P ＜0.01).Conclusions The level of H-FABP after surgery is an independent risk factor for the occurrence of PCE for the elderly patients undergoing non-cardiac thoracic surgery.It can predict the risk of PCE after non-cardiac thoracic surgery in aged patients.
