Association study of PRM2 gene polymorphism with male infertility in the 386 Chinese Han population
10.3969/j.issn.1671-8348.2016.16.017
- VernacularTitle:PRM 2 G398C多态性与386例汉族男性生育力的相关性研究
- Author:
Jun LI
;
Fang LIU
;
Xuemei YANG
;
Yaman SONG
;
Yanping FENG
;
Yuzhe TAN
- Publication Type:Journal Article
- Keywords:
protamine 2;
polymorphism,single nucleotide;
infertility,male;
genetic susceptibility
- From:
Chongqing Medicine
2016;45(16):2215-2216,2219
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the association of one single nucleotide polymorphism loci G 398C in PRM2 with male in‐fertility in Chinese Han population .Methods A total of 386 infertile men were recruited as the observation group and 255 fertile men were recruited as the control group .Routine semen analysis as well as sperm functional parameters such as DNA integrity and nucleoprotein maturity rates were analyzed .Direct sequencing of G398C in PRM2 gene of infertile and fertile men was also conduc‐ted to evaluate the association of G398C SNP loci with male infertility .Results Statistical analysis showed that the frequencies of CC genotype of PRM2 G398C was significantly different between the infertile (11 .92% ) and fertile men (6 .67% ) and it was asso‐ciated with increased risk of male infertility (OR= 2 .002 ,95% CI= 1 .097 -3 .653 ,P< 0 .05) .Moreover ,it was discovered that sperm DNA integrity as well as nucleoprotein maturity rate of CC genotype were dramatically decreased compared with other geno ‐types (P<0 .05) ,which would probably lead to infertility .Conclusion Our results gave the first evidence that PRM 2 G398C poly‐morphism was associated with male infertility in Chinese Han population .
