Efficaey of sulfasalazine in the treatment of epilepsy caused by gliomas
10.3969/j.issn.1671-8348.2016.17.018
- VernacularTitle:柳氮磺胺吡啶对神经胶质瘤致癫痫的疗效研究
- Author:
Dongwei XIE
;
Xinde ZHAO
;
Zhongbao ZHOU
;
Qijin HUANG
- Publication Type:Journal Article
- Keywords:
glioma;
epilepsy;
sulfasalazine;
glutamate
- From:
Chongqing Medicine
2016;45(17):2360-2361,2364
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy of sulfasalazine for treatment for epilepsy induced by gliomas .Methods The patients with epilepsy caused by gliomas in neurosurgery department were recruited from March 2006 to December 2013 .Epilepsy was controlled with sulfasalazine .The efficacy of sulfasalazine for treatment for epilepsy induced by glioma were analyzed to calcu-late the 50% response rate ,75% response rate and seizure-free rate .Meanwhile the outcomes scores of therapy of sulfasalazine for varieties types of epilepsy were evaluated ,according to the end result of scoring criteria in epileptic seizures .Results A total of 31 patients were controlled with sulfasalazine .The average reduction rate of seizure frequency per month was 54 .32% ,61 .71% , 75 .74% after three months of treatment .The differences of average reduction rate of seizure frequency before and after the treat -ment have an evident statistic significance (P< 0 .01) .The 50% response rate ,75% response rate and seizure-free rate per month af-ter treatment with sulfasalazine have significant higher than those before treatment (F= 20 .007 ,P< 0 .01) .After 3 month of thera-py ,four different types of epilepsy was 100 .00% ,100 .00% ,84 .62% and 75 .00% in improvement rate added complete control rate .Those have no statistical difference(P> 0 .05) .Conclusion Sulfasalazine can effectively control seizures ,and both effective va-rious types of epileptic .
