The construction of Alzheimer′s disease rats model and the effects of puerarin on rat spatial learning and memory
10.3969/j.issn.1671-8348.2016.16.007
- VernacularTitle:阿尔茨海默病大鼠模型建立及葛根素对大鼠空间学习记忆的影响
- Author:
Dong LI
;
Yin TIAN
;
Yu GONG
;
Xi WANG
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
puerarin;
spatial learning and memory
- From:
Chongqing Medicine
2016;45(16):2180-2181,2185
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the effects of puerarin on Alzheimer′s disease(AD) rats spatial learning and memory dis‐order induced by Aβ1‐42 .Methods Bilateral hippocampal injection of Aβ1‐42 was used to induced AD model rats .All rats under‐went gavage administration with puerarin with different dose for 28 d since the 3rd day after the construction of model ;and the Morris water maze was used to test the spatial learning and memory ability of rats .Results The model group rats showed obvious learning and memory disorder ,and the ability of learning and memory disorder of rats in the high ,medium and low dose of puerarin interven‐tion group were significantly improved .Conclusion Puerarin can improve the spatial learning and memory ability of AD model rats .
