Research of miRNA differential expression of AIDS with the syndrome of heat-toxic accumulation

VernacularTitle:艾滋病热毒蕴结证的 miRNA 差异表达研究
Author: Cen JIANG ; Chunhui CAO ; Baixue LI ; Quansheng FENG
Publication Type:Journal Article
Keywords: AIDS; heat-toxic accumulation; miRNA; target gene
From: Chongqing Medicine 2016;45(17):2365-2366,2369
CountryChina
Language:Chinese
Abstract: Objective The Study the difference of miRNA expression of AIDS patients with toxic heat accumulation syn -drome with healthy control group .Methods This research used Agilent miRNA chip to test the miRNA of blood preparation ,and used SAS system to screen the differences between groups ,then analyzed the significance function of target gene .Results Compare the heat-toxic accumulation group and the healthy control group ,100 cases of obvious expression difference and of which the differ-ence was 2 times and greater were screened out (in which 64 cases showed up-regulation and 36 showed down-regulation) .Differen-tially expressed miRNAs function involves the role of IL-21 receptor in T cell activation ,C reactive protein ,and the positive regula-tion of the immune response .Conclusion AIDS toxic heat accumulation syndrome patients and healthy control groups exist differ -ences in miRNA expression profiles ,the biological basis of syndrome maybe related to T cell activation and IL-21 receptor .