Analysis of false positive results by TP-ELISA analysis in elderly

VernacularTitle:老年人群梅毒抗体酶联免疫吸附试验检测假阳性结果原因分析
Author: Hongpeng YANG ; Li ZHAO ; Lin LIU
Publication Type:Journal Article
Keywords: Syphilis; The elderly population; False positive
From: Chinese Journal of Primary Medicine and Pharmacy 2016;23(14):2220-2221,2222
CountryChina
Language:Chinese
Abstract: Objective To investigate the causes of high rate of false positives in the detection of syphilis in elderly patients.Methods We used RPR,TP -ELISA and TPPA to detect the antibody of syphilis in 1 200 patients, and the samples were divided into the elderly group (60 or higher)and the control group (<60 years old),confirmed by TPPA,then counted the positive rate and false positive rate,and the results were analyzed.Results The positive rate (8.00%)and false positive rate (4.50%)of the elderly group were significantly higher than the control group (3.83%,1.87%,χ2 =9.36,9.47,all P <0.05).The false positive rate significantly rised with the increase of age of the elderly group.Conclusion The reason of false positive may be associated with the physical condition of the patients,and we should consider it with the clinical manifestations when diagnosed.