Expression and clinical significance of serum angiopoietin-2 in patients with chronic heart failure
10.7652/jdyxb201603007
- VernacularTitle:慢性心力衰竭患者血清血管生成素-2的表达及临床意义
- Author:
Haoyu WU
;
Chunyan ZHANG
;
Lei LIANG
;
Congxia WANG
;
Xiling SHOU
;
Yan ZHANG
;
Weidong MA
;
Shan JIA
;
Yang ZHENG
;
Xiaohuan LIU
- Publication Type:Journal Article
- Keywords:
chronic heart failure;
angiopoietin-2;
N-terminal pro-B-type natriuretic peptide;
left ventricular ejection fraction;
correlation analysis
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2016;37(3):336-338,348
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of serum angiopoietin-2 (Ang-2 ) and its clinical significance in patients with chronic heart failure (CHF).Methods The levels of serum Ang-2,N-terminal pro-B-type natriuretic peptide (NT-proBNP)and left ventricular ejection fraction (LVEF)were detected in 1 1 3 patients with CHF,who were divided into four groups according to New York Heart Association (NYHA:class Ⅰ,n=3 2;Ⅱ,n=30;Ⅲ,n=26;Ⅳ,n=25).Another 20 healthy volunteers for physical check-up were chosen as the control group.Results With the change of cardiac function (from Ⅰ to Ⅳ),the levels of plasma Ang-2 and NT-proBNP were increased significantly (P<0.05 ).The level of serum Ang-2 was positively correlated with NT-proBNP (r=0.774,P<0.001),but negatively correlated with left ventricular ejection fraction (r=-0.725,P<0.001).Conclusion The level of serum Ang-2 has a significant correlation with the severity of heart failure.Ang-2 is expected to be used to predict and evaluate the severity of CHF.
