Research progress on association of LRP6 gene polymorphism and metabolic syndrome
10.3969/j.issn.1001-1978.2016.05.003
- VernacularTitle:LRP6基因多态性与代谢综合征的相关性研究进展
- Author:
Zhenmin WANG
;
Jianquan LUO
;
Wei ZHANG
- Publication Type:Journal Article
- Keywords:
Wnt signaling pathway;
LRP6;
metabolic syndrome;
typeⅡdiabetes;
hyperlipidemia;
atherosclerosis;
CAD
- From:
Chinese Pharmacological Bulletin
2016;32(5):603-606,607
- CountryChina
- Language:Chinese
-
Abstract:
Metabolic syndrome is the fundamental factor in the pathogenesis of a variety of diseases, and it has not yet been fully understood due to its complicated mechanism. Multiple re-searches have implicated that Wnt/β-catenin signaling pathway may have a significant effect on the formation and development of metabolic syndrome. LRP6 is an important co-receptor of Wnt/β-catenin signaling pathway ,and there are some researches im-plicating the correlation between LRP6 and metabolic syndrome. The in-depth research on the gene polymorphism and its modula-tion mechanism can provide new ideas and directions for meta-bolic syndrome therapy.
