Relationship of CD31+/CD42b- and CD144+ endothelial micropaticles with intima-media thickness of carotid artery
10.7652/jdyxb201603005
- VernacularTitle:CD31+/CD42b-、CD144+内皮微粒水平与颈动脉内膜中层厚度的关系
- Author:
Xiaohui QUAN
;
Chunyan ZHANG
;
Congxia WANG
;
Yan ZHANG
;
Shan JIA
;
Weidong MA
;
Xuan GUO
;
Xiaohuan LIU
;
Yang ZHENG
- Publication Type:Journal Article
- Keywords:
endothelial microparticles;
carotid intima-media thickness;
Doppler
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2016;37(3):327-330,335
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the levels of CD31+/CD42b- and CD144+ endothelial microparticles (EMPs)in plasma,and analyze the relationship with carotid intima-media thickness (CIMT)and the risk factors of atherosclerosis.Methods Totally 122 outpatients and inpatients in our hospital were selected,and carotid artery ultrasound examination was performed.The results were divided into a thickening group (62 cases)and a control group (60 cases).Flow cytometry was used to detect the levels of CD31+/CD42b- and CD144+ EMPs in the blood to analyze the relationship between the level of endothelial cells and CIMT,and to investigate the relationship between the level of plasma EMPs and the risk factors of atherosclerosis.Results Compared with the control group,the levels of EMPs of CD31+/CD42b- and CD144+ were significantly higher.In the correlation analysis, plasma CD31+/CD42b- and CD144+EMPs levels were positively correlated with CIMT;in multi-factor Logistic regression analysis,CD31+/CD42b- EMPs levels were correlated positively with age,TC and Cys C;plasma CD144+ EMPs levels were correlated with UA and BMI.Conclusion The levels of CD31+/CD42b-,CD144+EMPs in plasma were correlated with CIMT,guiding early prevention of cardiovascular diseases.
