Association of rs10004195 single nucleotide polymorphisms in Toll like receptor 10 gene with helicobacter pylori infection and associated diseases
- VernacularTitle:Toll样受体10基因rs10004195位点多态性与Hp感染以及相关疾病的关系
- Author:
Ying SHU
;
Pingan ZHANG
;
Yongqing TONG
- Publication Type:Journal Article
- Keywords:
Toll like receptor 10 gene;
single nucleotide polymorphism;
helicobacter pylori
- From:
Acta Universitatis Medicinalis Anhui
2016;51(5):728-730,731
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of rs10004195 single nucleotide polymorphisms in Toll like re-ceptor 10(TLR 10) gene with helicobacter pylori infection and associated diseases. Methods A total of 652 pa-tients who has been examined by gastroscopy were obtained, and then peripheral blood samples were collected from all the patients. Immune colloidal gold method was used to test the serological Hp antibody of all the patients. The TLR10 gene rs10004195 polymorphisms were examined by direct DNA sequencing of the PCR products. Results The frequencies of AA,TT and AT genotype on TLR10 rs10004195 were 30. 98%, 20. 71%, 48. 31%;there was significant difference between Hp antibody positive group and Hp antibody negative group in the TT frequencies of TLR10 rs10004195 ( P<0. 05 ) . No significant difference between controls and Hp associated diseases groups in Hp antibody positive group or in Hp antibody negative group were observed. Conclusion There was correlation be-tween the TLR10 rs10004195 loci genotype and the risk of Hp infection, but no correlation with Hp associated dis-eases.
