Comparison of the influence of different HBV genotypes and subgenotypes to patients 'immune function

VernacularTitle:乙型肝炎病毒不同基因亚型对患者免疫功能的影响比较
Author: Lu LU ; Yanqin HAO ; Hong LI ; Qinying WANG
Publication Type:Journal Article
Keywords: Hepatitis,type B,chronic; Genotypes and sub -genotypes; Cytokines
From: Chinese Journal of Primary Medicine and Pharmacy 2016;23(9):1292-1294,1295
CountryChina
Language:Chinese
Abstract: Objective To compare the influence of different genotypes of hepatitis B virus to the body's immune function.Methods 377 patients with chronic hepatitis B virus (serum HBV DNA are all positive)were selected.The serum specimens were collected.Nest PCR method was used to detect all entrants subtype HBV genotypes,ELISA method was used to detect serum levels of IL -10 and IL -17,fully automatic biochemical instrument was used to test all entrants liver function.Results Of 377 patients with chronic hepatitis B,C genotype in 323 cases,C2 type in 321 cases (85.1%),C1 type 2 cases (0.5%);Genotype B 41 cases (10.9%),were B2 subtype;B and C mixed 12 cases (3.2%);Type D in 1 case (0.3%).The sex,age,ALT,AST,TBIL of B2,C2 subtypes,BC mixed infection had no statistically significant differences.B2,C2 subtypes,BC mixed infection had no statistically significant difference in serum IL -17 level.And B2,C2 subtype infection had statistically significant difference in IL -10 level (F =0.444,P <0.05).Conclusion Different genotype HBV subtypes may have different effect to the body's immune function.