Survival analysis of patients with high risk refractory lymphoma treated by autologous hematopoietic stem cell transplantation
10.3969/j.issn.1671-8348.2016.12.011
- VernacularTitle:自体造血干细胞移植治疗高危难治淋巴瘤生存分析
- Author:
Xin PU
;
Jieping CHEN
- Publication Type:Journal Article
- Keywords:
hematopoietic stem cell transplantation;
lymphoma;
transplantation,autologous;
prognosis
- From:
Chongqing Medicine
2016;45(12):1620-1623,1626
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prognosis and survival situation of the patients with high risk refractory lymphoma treated by autologous hematopoietic stem cell transplantation .Methods The follow up data in 110 patients with high risk refractory lymphoma treated by autologous hematopoietic stem cell transplantation in our hospital were retrospectively analyzed .The survival and prognosis factors of the patients after autologous hematopoietic stem cell transplantation were analyzed by using the Kaplan-Meier survival analysis and Cox proportional hazard regression analysis .Results The median survival time was 39 .4 months in 110 cases ,the 3‐year overall survival rate (OS) and progression free survival rate (PFS) were 80 .9% and 76 .4% respectively .The pa‐tients achieved CR status before transplantation(P=0 .016) and consolidation therapy after transplantation (P=0 .006) were the favorable prognostic factors of the patients undergoing transplantation .The prognosis in the patients with high LDH values ,IPI score>2 and bone marrow infiltration and HBV infection were poor(P<0 .05) .Conclusion Autologous hematopoietic stem cell transplantation can improve the long‐term survival rate in the patients with high risk refractory lymphoma .
