Clinical analysis of microelectrode guided stereotactic functional nucleus lesioning operation in treatment of Parkinson′s disease
10.3969/j.issn.1671-8348.2016.12.019
- VernacularTitle:微电极引导立体定向功能核团毁损术治疗帕金森病的临床分析
- Author:
Jinfeng LOU
;
Keliang CHANG
;
Xiaoteng GENG
;
Guangming NIU
;
Shengzhong TAO
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
nucleus lesioning;
microelectrode
- From:
Chongqing Medicine
2016;45(12):1645-1646,1649
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the application of microelectrode stereotactic functional nucleus lesioning operation in the treatment of Parkinson′s disease(PD) ,and to explore its clinical value .Methods The clinical data in 84 cases of PD treated with‐out using the microelectrode stereotactic functional nucleus lesioning operation(observation group) and 74 cases of PD treated by u‐sing microelectrode guided stereotactic functional nucleus lesioning in our hospital were retrospectively analyzed .At the same time the Unified Parkinson′s Disease Rating Scale (UPDRS) scores before the nucleus lesioning and at postoperative different medication states were obtained in the observation and the control group .Furthermore the difference of the UPDRS motor scores before and af‐ter operation were compared between the two groups .Results The UPDRS motor scores at postoperative 3 ,6 months and 1 year in the observation group were significantly improved compared with before operation(P<0 .05) ,meanwhile the postoperative anti‐PD drug dosage was significantly decreased compared with before operation(P<0 .05) .Among them ,70 cases(83 .3% ) in the control group were obviously effective ,14 cases(16 .7% ) were effective ,and the total effective rate was 100% ;while 62 cases(83 .7% ) in the observation group were obviously effective ,12 cases (16 .3% ) were effective ,and the total effective rate was 100% .The differ‐ence in improving the UPRDS motor scores before and after operation had no statistical difference between the two groups(P>0 .05) .Conclusion Stereotactic nucleus lesioning in treating PD has satisfactory effect and can significantly improve the UPRDS motor scores .Accurate positioning is the key to the operation success ,whether microelectrode recording can significantly improving the operation accuracy needs further discussion .
