Status of the non-sentinel lymph node metastasis in breast cancer patients with small number of positive sentinel lymph node

VernacularTitle:乳腺癌低负荷前哨淋巴结阳性对非前哨淋巴结转移的预测分析
Author: Wenyan WANG ; Xin WANG ; Jie WANG ; Jidong GAO ; Lixue XUAN
Publication Type:Journal Article
Keywords: Breast cancer; Sentinel lymph node; Lymphatic metastasis
From: Chinese Journal of Endocrine Surgery 2016;10(2):144-147,151
CountryChina
Language:Chinese
Abstract: Objective To explore the risk factors and metastasis of non-sentinel lymph node (NSLN) in breast cancer patients with sentinel lymph node metastasis≤2. Methods 88 cases of breast cancer with sentinel lymph node metastasis≤2 were retrospectively analyzed. Factors influencing the status of NSLN were studied. Results 8 cases (9.09%) had NSLN metastasis. Variance analysis showed that tumor stage(P=0.014), histolog-ical grade(P=0.014) and ER statuts(P=0.009) were correlated with NSLN metastasis. Logistic analysis showed that only histological grade was the independent predictor for NSLN metastasis (P=0.016,OR=1.150,95%CI=0.598~7.740).18 cases had micro-metastasis of sentinel lymph node and 70 cases had macro-metastasis of sentinel lymph node. The ratio of false negative SLN was 10.23%. The mean follow-up time was 11 months. There was no case of recurrence, metastasis or death. Conclusions The metastasis rate of NSLN is relatively low in breast cancer patients with small number of positive SLNs. NSLN metastasis is related to tumor stage, histological grade, and ER expression.