The efficacy of methylprednisolone injection and magnesium sulfate injection in the treatment of severe bronchial asthma and its influenc on inflammatory factors
10.3760/cma.j.issn.1008-6706.2016.10.037
- VernacularTitle:甲泼尼龙注射液和硫酸镁注射液治疗重症支气管哮喘的疗效及对炎性因子的影响
- Author:
Chuming YANG
;
Yimin XU
- Publication Type:Journal Article
- Keywords:
Asthma;
Methylprednisolone injection;
Magnesium sulfate injection;
Inflammation media-tors
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(10):1572-1574,1575
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy of methylprednisolone injection and magnesium sulfate injection in the treatment of severe bronchial asthma and the impact on inflammatory cytokines.Methods 87 cases of severe bronchial asthma were selected for the study,and they were divided into two groups according to the order of admission,the control group (43 cases ) was given methylprednisolone treatment,while the observation group (44 cases)was given methylprednisolone injection and magnesium sulfate treatment.The clinical treatment and inflammatory cytokine levels before and after treatment were compared between the two groups.Results The effective rate of the observation group was 93.18%,which was higher than 74.42% of the control group,the difference was significant(χ2 =10.33,P <0.05 ).After treatment,pulmonary functions of the observation group [FVC (3.72 ± 0.42)L,FEV1 (2.72 ±0.32)L and PEF(3.48 ±0.49)L/s]were increased significantly than before treatment(t =7.87,7.81,8.41,all P <0.05),and had significant differences compared with the control group(t =6.93,7.44, 7.20,all P <0.05).After treatment,inflammatory cytokines indicators of the observation group[IL -6 (67.44 ± 0.43)μg/L,TNF -α(80.32 ±7.34)ng/L,hs -CRP(3.32 ±0.89)mg/L]were significantly increased than before treatment(t =6.85,7.41,7.33,all P <0.05),compared with the control group,the differences were significant(t =6.55,7.04,6.45,all P <0.05).Conclusion The methylprednisolone combination with magnesium sulfate in treat-ment of severe bronchial asthma had significant effect,and it can effectively improve the airway inflammation,promote lung function in patients'recovery,and it has great clinical value.
