Corelationship between proton pump inhibitors and hospital-acquired pneumonia in abdominal surgical patients
10.3969/j.issn.1006-5725.2016.07.025
- VernacularTitle:质子泵抑制剂与腹部外科手术患者医院获得性肺炎的相关性
- Author:
Wei SU
;
Tingting ZHANG
;
Zili YANG
- Publication Type:Journal Article
- Keywords:
Sress ulcer bleeding;
Hspital-acquired pneumonia;
Proton pump inhibitors;
Hstamine-2 receptor antagonist
- From:
The Journal of Practical Medicine
2016;32(7):1118-1120,1121
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the corelationship between proton pump inhibitors (PPI) and the incidence of hospital-acquired pneumonia (HAP) in abdominal surgical patients. Methods A total of 283 cases admitted from 2010 to 2014 were divided into PPI group (n = 326) and HRA group (n = 92). In PPI group, patients were divided into omeprazole subgroup (subgroup A, n = 146), lansoprazole subgroup (subgroup B, n = 102) and pantoprazole subgroup (subgroup C, n = 78) by the types of PPI. In HRA group, patients were divided into famotidine subgroup (subgroup D, n = 58) and ranitidine subgroup (subgroup E, n=34) by the types of histamine-2 receptor antagonist (H2RA). The incidence of stress ulcer bleeding (SUB) and HAP were calculated, while mechanical ventilation period (MV), ICU stay and 28-day-mortality were compared. Results There were lower incidences of SUB and HAP, shorter MV and ICU stay and lower 28-day-mortality in PPI group than those in HRA group (P < 0.05). In three subgroups of PPI group, there were no significant difference on incidence rate of SUB and HAP, as well as MV, ICU stay and 28-day-mortality. Conclusion The incidence rates of SUB and HAP are lower by using PPI than H2RA in abdominal surgical patients, as well as MV, ICU stay and 28-day-mortality. Different types of PPI have no effect on the incidence rate of HAP in abdominal surgical patients.
