Influence of sufentanil preconditioning on early cognitive function and myocardial protection in patients undergoing on-pump CABG
10.3969/j.issn.1008-0074.2016.01.18
- VernacularTitle:舒芬太尼预处理对冠脉旁路移植术围术期认知功能和心肌保护的作用
- Author:
Yi LEI
;
Longfang ZHANG
;
Shenyi LI
;
Jiancheng HUANG
;
Ruoyun QIAN
- Publication Type:Journal Article
- Keywords:
Ischemic preconditioning,myocardial;
Coronary artery bypass;
Sufentanil
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2016;25(1):62-66,67
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe influence of preoperative sufentanil delayed preconditioning (SPC) on perioperative cogni‐tive function and myocardial protection effect in patients undergoing on -pump coronary artery bypass grafting (OP‐CABG) .Methods:A total of 60 patients undergoing selective OPCABG were randomly and equally divided into sufentanil group (SPC group) and routine treatment control group (control group) ,blood sample was collected before operation ,1h , 6h ,12h ,24h and 48h after aorta declamping to measure level of cardiac troponin I (cTnT );and all patients received neu‐ropsychological assessment before and 7d after operation .Results:Compared with control group ,there was significant re‐ductions in serum cTnI levels [1h:(23.66 ± 3.15) ng/ml vs .(14.96 ± 2.13) ng/ml] in sufentanil group from 1h after aor‐ta declamping to 48h after CABG ,P<0.05 all .The inotropic agent usage score on 12h ,24h and 48h after entering ICU of sufentanil group was significantly lower than that of control group [12h:(6.4 ± 0.6) scores vs .(8.4 ± 0.6) scores] , P<0.05 all .Incidence rate of postoperative cognitive dysfunction (POCD) in sufentanil group was significantly lower than that of control group (13.3% vs .30.0% ,P=0.041) .Conclusion:Preoperative sufentanil delayed preconditioning posses‐ses myocardial protection effect , and reduce incidence rate of cognitive dysfunction so also possesses certain brain protection in patients undergoing on-pump coronary artery bypass grafting .
