Research progress of NLRP3 inflammasome in atherosclerosis-related cells
10.3969/j.issn.1001-1978.2016.02.004
- VernacularTitle:NLRP3炎症小体在动脉粥样硬化相关细胞中作用的研究进展
- Author:
Fang BIAN
;
Si JIN
- Publication Type:Journal Article
- Keywords:
NLRP3 inflammasome;
IL-1β;
atherosclerosis;
en-dothelial cells;
macrophages;
vascular smooth muscle cells
- From:
Chinese Pharmacological Bulletin
2016;(2):163-168,169
- CountryChina
- Language:Chinese
-
Abstract:
Inflammasome, which is a large multiprotein complex in the cytosol regulating IL-1β production, plays an important role in atherosclerosis ( AS ) . To date, NLRP3 ( nucleotide-binding domain and leucine-rich repeat protein 3) inflammasome is the most widely studied type of inflammasome. This article aims to review the effects of NLRP3 inflammasome on AS-related cells ( endothelial cells, macrophages and vascular smooth mus-cle cells) to further explore the role of NLRP3 inflammasome in the progression of AS.
