Serological diagnosis methods of schistosomiasis japonica at different preva-lence:a meta-analysis
10.16250/j.32.1374.2015170
- VernacularTitle:不同流行程度下日本血吸虫病血清学诊断方法的 Meta 分析
- Author:
Xinyao WANG
;
Kun YANG
- Publication Type:Journal Article
- Keywords:
Schistosomiasis japonica;
Indirect hemagglutination test(IHA);
Enzyme-linked immunosorbent assay(ELI-SA);
Dipstick dye method(DDIA);
Sensitivity;
Specificity;
Diagnostic effectiveness;
Meta-analysis
- From:
Chinese Journal of Schistosomiasis Control
2016;(1):18-25,29
- CountryChina
- Language:Chinese
-
Abstract:
Objective To comprehensively evaluate the effects of indirect hemagglutination test(IHA),enzyme?linked im?munosorbent assay(ELISA),and dipstick dye method(DDIA)in the diagnosis of schistosomiasis japonica at different preva?lence by using Meta?analysis. Methods Through the literature review according to the inclusion and exclusion criteria,a data?base was established,and by using Meta?disc and R software,the Meta?analysis was performed including the threshold test,het?erogeneity test,weighted by the quantitative effect of merger,SROC curve fitting,etc. Results A total of 60 papers were in?cluded in the final analysis. The sensitivities of IHA were 0.84,0.76 and 0.94 in heavy,medium and low endemic areas,and specificities were 0.73,0.64 and 0.73 respectively;the sensitivities of ELISA were 0.88,0.80 and 0.93 in heavy,medium and low endemic areas,and the specificities were 0.59,0.59 and 0.62 respectively;the sensitivities of DDIA were 0.93,0.81 and 0.93 in the heavy,medium and low endemic areas,and specificities were 0.66,0.69 and 0.59 respectively. The weighted sensi?tivities of IHA,ELISA and DDIA were 0.83,0.87 and 0.90 respectively;the weighted specificities were 0.69,0.60 and 0.62 re?spectively. The areas under the curve of SROC were 0.89,0.96 and 0.92 in IHA,ELISA and DDIA respectively. Conclusions In different prevalence,the effectiveness of different methods for serological diagnosis of schistosomiasis is different. The sensi?tivity and specificity of all diagnostic methods of schistosomiasis need to further improve.
