Hepatitis C virus genotyping of Han and Uygur patients in Xinjiang Uygur autonomous region
10.3969/j.issn.1671-8348.2016.01.005
- VernacularTitle:新疆汉族、维吾尔族丙型肝炎感染者 HCV 基因型研究
- Author:
Zhaoyun CHEN
;
Na XIE
;
Zhaoxia ZHANG
;
Cunren MENG
;
Ting GU
;
Jianmei ZHAO
;
Chen ZHANG
- Publication Type:Journal Article
- Keywords:
Xinjiang;
hepatitis C;
genotype
- From:
Chongqing Medicine
2016;(1):14-16,18
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the genotyping characteristics of Han and Uygur patients with hepatitis C virus(HCV) in Urumqi and other area of Xinjiang ,and provide information for diagnosis and treatment .Methods Totally 380 samples of Han and Uygur patients virus load were detected by real - time PCR ,with the load greater than 1 × 103 copies/mL ,HCV genotyping was carried out by PCR - reverse dot blot hybridization .Results A total of 355 samples(93 .4% ) was genotyped successful .Type 1b of Han and Uygun were 59 .91% ,69 .92% ,type 2a were 30 .17% ,12 .20% ,type 3a were 5 .60% ,8 .13% and type 3b were 3 .88% , 8 .94% .In Urumqi and other areas ,significant difference of patient distribution ,male and female were found between Han and Uygur patients(all P< 0 .05) ,In Urumqi ,type 2a had significant difference between Uygur and Han male patients ,type 1b ,3b had significant difference in female patients(P< 0 .05) .In other areas except Urumqi ,type 2a had significant difference between Uygur and Han man(P< 0 .05) ,other genotypes were not found difference(P> 0 .05) .Conclusion HCV genotyping of Uygur and Han patients in Xinjiang is different with the majority areas in China ,type 1b and 2a are the main infectious virus in Han ,and type 1b is the main infectious virus in Uygur ,followed by type 2a ,3a ,3b .
