Influence of tongxinluo on blood endothelial microparticles and MMP-9 in patients with acute myocardial infarction after percutaneous coronary intervention
10.3969/j.issn.1671-8348.2016.03.021
- VernacularTitle:通心络对急性心肌梗死患者PCI术后血清EMPs及MMP-9的影响
- Author:
Hongkun LI
;
Yongguang LU
;
Hua YAN
;
Junzhang HUANG
;
Dongming HE
;
Changzhi QIU
- Publication Type:Journal Article
- Keywords:
myocardial infarction;
coronary artery disease;
matrix metalloproteinase-9;
endothelial microparticles;
tongxinluo
- From:
Chongqing Medicine
2016;(3):354-355,361
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study influence of tongxinluo on blood endothelial microparticles(EM Ps) and matrix metalloprotei‐nase‐9(MMP‐9) in patients with acute myocardial infarction after percutaneous coronary intervention(PCI) .Methods One hundred and twenty‐eight hospitalized patients with acute myocardial infarction after per‐cutaneous coronary intervention were recruited from January 2012 to December 2014 ,All patients were randomly divided into tongxinluo group (n=65) and control group (con‐ventional treatment ,n=63) .Tongxinluo group was on the basis of conventional treatment group with tongxinluo capsules 2 plus ,3 times a day .We detected the EMPs and MMP‐9 of two groups preoperatively and on the 7th postoperatively day .Results Com‐pared with the conventional treatment group ,blood EMPs and MMP‐9 in tongxinluo group were lower after 7 days treatment ,the difference was statistically significant (P<0 .05) .There was a positive correlation between the EMPs and MMP‐9(P<0 .05) .Con‐clusion For patients with acute myocardial infarction after percu‐taneous coronary intervention ,tongxinluo could further inhibit in‐flammatory reaction ,make the plaque stability and improve the function of endothelial cells on the basis of conventional treatment groups .
