Progress of TRIB3 gene research
10.3760/cma.j.issn.1008-6706.2016.04.037
- VernacularTitle:TRIB3基因的研究进展
- Author:
Shaoting DONG
- Publication Type:Journal Article
- Keywords:
Oncogenes;
TRIB3
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;(4):625-626,627
- CountryChina
- Language:Chinese
-
Abstract:
Tribbles homolog 3(TRIB3,also named TRB3,NIPK,and SKIP3)belongs to the tribbles family of pseudokinases,that were first identified in Drosophila to regulate cell division and migration.TRIB3 expression is upregulated by endoplasmic reticulum stress,hypoxia,and nutrient starvation.Previous studies showed that TRIB3 expression was closely related to the progression of type 2 diabetes mellitus,and that TRIB3 mediated apoptosis in islet beta cells,as well as insulin resistance.Recent studies suggested that TRIB3 is a potential oncogene,as evidenced by its elevated expression in colorectal cancer,breast cancer,liver cancer and other cancer tissues.
