Effect of Compound Yibazhen Granules on Early Renal Injury in Spontaneous Hypertensive Rats
10.3870/j.issn.1004-0781.2016.02.004
- VernacularTitle:复方一把针颗粒对原发性高血压大鼠高血压早期肾损伤的影响?
- Author:
Xinli LIN
;
Zhuyuan FANG
;
Xuanxuan ZHU
;
Haidan WANG
;
Rui FU
;
Di ZHANG
;
Xuefei ZHANG
- Publication Type:Journal Article
- Keywords:
Compound Yibazhen granules;
Spontaneously hypertensive rats;
Angiotensin Ⅱ;
Nitrogen monoxidum synthase;
Nitric oxide
- From:
Herald of Medicine
2016;(2):125-128,129
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the antihypertensive effect of compound Yibazhen granules on spontaneous hypertensive rats ( SHR) . Methods Wistar rats were served as normal control group. Sixty SHR were randomly divided into model control group,captopril group,Jane chrysanthemum antihypertension tablet group and compound high dose group,middle dose group and low dose group ( n = 10 each group ) by digital table method. Captopril group was given captopril 30 mg.kg-1 .d-1 ,and Jane chrysanthemum antihypertension tablet group was treated with Jane chrysanthemum antihypertension tablet ( 0. 6 tablet per kg ) , compound Yibazhen granules high dose group, middle dose group and low dose group received compound of 13.18,6.59 and 3.3 mg.kg-1 .d-1 ,respectively. Normal control group and model control group were intragastrically administered with 0.9% sodium chloride solution for 8 weeks. Changes of systolic and diastolic blood pressure of rats and blood urea,creatinine,nitric oxide (NO),nitric oxide synthase (NOS) and angiotensin Ⅱ (Ang Ⅱ) were observed. Results Diastolic pressure of rats in compound Yibazhen granules high dose group, middle dose group and low dose group decreased significantly in 2 weeks. Systolic blood pressure and diastolic blood pressure of compound Yibazhen granules high dose group decreased significantly in 4 weeks,compared with the model control group (P<0.05). Compared with the model control group, concentration of urea and crea in compound Yibazhen granules high dose group, middle dose group and low dose group were significantly lower( P<0.05) . The content of NOS and AngⅡ in rats of compound Yibazhen granules high dose group decreased significantly and the contents of NO increased, which were compared with the model control group ( P<0. 05, P<0. 01 ) . Conclusion The protective effect of compound Yibazhen granules in treating early renal damage in SHR is related to decreasing diastolic blood pressure,concentration of urea,crea and AngⅡ and regulating the levels of NOS and NO.
