Correlations between quantitative parameters of dynamic contrast -enhanced MRI and nasopharyngeal carcinoma clinical stage
10.3760/cma.j.issn.1008-6706.2016.06.011
- VernacularTitle:磁共振动态增强成像定量参数与鼻咽癌临床分期的相关性
- Author:
Kun SONG
;
Hua WANG
;
Ruijun NI
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal neoplasms;
Magnetic resonance imaging;
Clinical staging
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(6):841-843,844
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlations between quantitative parameters of dynamic contrast-enhanced MRI ( DCE-MRI) and nasopharyngeal carcinoma ( NPC) clinical stage.Methods 69 patients with NPC were selected from Oct 2013 to Oct 2015 in Shaoxing People's Hospital,39 men and 30 women,aged 39-76 years old,average 50.6 ±10.5 years old.All patients underwent clinical staging,DCE-MRI and histopathological examina-tion before treatment.Clinical stages were determined based on Chinese 2008 staging system.Value of the volume transfer constant ( Ktrans) and the extravascular extracellular space volume per unit volume of tissue ( Ve) was detec-ted by bi-compartmental pharmacokinetic model.The correlations between quantitative parameters and clinical stage were analyzed by Pearson correlation analysis.Results Mean Ktrans and Ve for NPC were (0.532 ±0.156) mL/min/100cm3 and (0.982 ±0.356),respectively.Ktrans of NPC showed negative correlation with clinical stage (r=-0.506,P=0.001),T stage (r=-0.326,P=0.014),N stage (r=-0.296,P=0.017) and M stage (r=-0.312,P=0.015),while Ve showed positive correlation with clinical stage (r=0.415,P=0.002),T stage (r=0.478,P=0.001),N stage (r=0.318,P=0.015) and M stage (r=0.346,P=0.011).Conclusion DCE-MRI quantitative parameters are significantly related to clinical stage of NPC,which has important values for clinical treat-ment and prognostic assessment.
