The correlation research between three ultrasonic technologies for the measurement error in breast cancer and the expression of ER, PR and VEGF
10.3760/cma.j.issn.1008-6706.2016.05.001
- VernacularTitle:三种超声成像技术对乳腺肿瘤大小的测量误差与雌激素受体、孕激素受体、血管内皮生长因子表达的相关性研究
- Author:
Peiwei CAI
;
Teng LIN
;
Xiaohuan ZHU
;
Cong HUANG
;
Yingbin XU
;
Weizhen LIAN
;
Guoliang GONG
;
Qiancheng QIU
;
Baoan WU
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Breast neoplasms;
Immunohistochemistry;
Measuring method
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(5):641-644,645
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the three ultrasonic technologies of two -dimensional ultrasound(2D -US),ultrasonic elastography(UE) and contrast -enhanced ultrasound(CEUS) for the measurement error in breast cancer and the correlation with the expression of ER,PR,VEGF.Methods 50 patients with breast cancer were meas-ured by 2D -US,UE,CEUS preoperatively,and the pathological specimen were measured postoperatively.Then used the immunohistochemistry to detect the expression of ER,PR,VEGF in tumor,and analyzed the correlation with the measurement errors.Results The results of differences between 2D -US,UE,CEUS and pathology were respectively as follows:( -0.59 ±-0.34)cm,( -0.20 ±-0.14)cm,( -0.40 ±-0.31)cm,and the differences were statistically significant(F =20.497,P <0.001).The positive expression rate of ER and PR was high if the difference between UE and 2D -US was less than or equal to 0.44cm.And the positive expression rate of VEGF was low if the difference between CEUS and 2D -US was less than or equal to 0.19cm.Three ultrasonic technologies in the measurement of breast cancer were different,the trend of difference between UE and 2D -US was smaller if the ER and PR were positively expression,and the trend of difference between CEUS and 2D -US was bigger if the VEGF was positively expression.Conclusion There is correlation between different immunohistochemical expression of breast cancer with measurement error in three different ultrasonic imaging technologies.The results suggest that the molecular pathology difference of breast cancer can impact on ultrasonic imaging,which contributes to know the reason and regulation of measurement error in different ultrasonic imaging technology.
