Clinical observation and adverse reactions of different doses of mifepristone in treatment of uterine fibroids
10.3760/cma.j.issn.1008-6706.2016.07.011
- VernacularTitle:不同剂量米非司酮治疗子宫肌瘤的临床效果比较
- Author:
Zhanying WANG
- Publication Type:Journal Article
- Keywords:
Uterine leiomyoma;
Mifepristone;
Adverse reactions
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(7):1002-1004,1005
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the adverse reactions of different doses of mifepristone in treatment of uterine fibroids.Methods 60 patients with uterine fibroids were randomly divided into observation group and control group,30 cases in each group.The control group was treated with high dose mifepristone of 20 mg/d, while the observation group was given 10mg/d of low dose mifepristone.The clinical efficacy,uterine fibroid volume,uterine volume and adverse reactions occurrence between the two groups were compared.Results The effective rate of the observation group was 90.00%,which was significantly higher than 73.33% of the control group,the difference was statistically significant (χ2 =7.584,P<0.05).The uterine myoma size and uterine volume in the two groups after treatment were significantly lower than before treatment,which in the observation group after treatment were (35.74 ± 7.69)cm3,(139.54 ±12.57)cm3 and significantly lower than (49.21 ±8.55)cm3,(178.36 ±14.02)cm3 in the control group,the differences were statistically significant (t=7.846,8.229,all P<0.05).The occurrence rate of headache,loss of libido and the incidence of nausea and vomiting in the observation group were 0.00%,0.00%, 3.33%,which were significantly lower than 13.33%,16.67%,20.00% in the control group,the differences were statistically significant(χ2 =9.523,10.885,8.527,all P <0.05).Conclusion Low dose mifepristone in the treatment of uterine fibroids can significantly improve the clinical efficacy,reduce the incidence of adverse reactions, which is worthy of clinical promotion.
