The relationship of serum vitamin D3 level and inflammatory factor in primary hypertensive patients
10.3760/cma.j.issn.1008-6706.2016.05.017
- VernacularTitle:原发性高血压患者血清活性维生素 D和炎性因子水平及其相关性
- Author:
Jingjing XUE
;
Wenfeng YAN
;
Zhiming YANG
- Publication Type:Journal Article
- Keywords:
Hypertension;
Calcitriol;
Inflammatory factor;
Risk factors
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(5):705-707,708
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between serum 1,25 -dihydroxy vitamin D3 level and inflammatory factor in elderly primary hypertension patients.Methods Sixty -eight primary hypertension patients were selected as hypertension group,and 60 healthy subjects were selected as control group in this study.The serum 1,25 -dihydroxy vitamin D3 level and plasma inflammatory factor were measured and compared.Results The serum 1,25 -dihydroxy vitamin D3 level in the hypertension group was significantly lower,while plasma inflammatory factor in the hypertension group was significantly higher than in the control group(t =6.445,7.326,8.174,8.556,all P <0.01).Pearson correlation analysis showed that the serum 1,25 -dihydroxy vitamin D3 level was negatively related with systolic blood pressure,plasma diastolic blood pressure and inflammatory factor (r =-0.425, -0.367, -0.254, -0.263, -0.296,all P <0.05).Logistic repression analysis revealed that the inflammatory factor was a risk factor for hypertension,while the 1,25 -dihydroxy vitamin D3 level was a protecting factor for primary hypertension. Conclusion The serum 1,25 -dihydroxy vitamin D3 level is significantly lower in elderly primary hypertension patients than in healthy subjects.The serum 1,25 -dihydroxy vitamin D3 level and the inflammatory factor are predic-tive factors for hypertension.
