Preparation and in vitro Properties of Thermosensitive Liquid Suppositories of Mesalazine HP-β-CD Com-plex
- VernacularTitle:美沙拉嗪羟丙基β-环糊精包合物温敏型液体栓的制备及性质考察
- Author:
Xinglong SONG
;
Wen HE
;
Lingli ZHANG
;
Weihua LI
- Publication Type:Journal Article
- Keywords:
MSZ;
HP-β-CD;
Inclusion compound;
Thermosensitive liquid suppositories;
Preparation;
Properties in vitro
- From:
China Pharmacist
2016;19(4):639-641,642
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare thermosensitive liquid suppositories of mesalazine( MSZ) HP-β-CD complex and study the in vitro properties. Methods:Poloxamer 407 (P407) and poloxamer 188 (P188) were used as the thermosensitive polymers to load MSZ HP-β-CD complex to prepare the thermosensitive liquid suppositories. The viscosity, gel strength, bioadhesion,in vitro gel erosion and drug release of MSZ HP-β-CD complex were compared with those of MSZ liquid suppositories. Results: Compared with that of MSZ liquid suppositories, the gel temperature of MSZ HP-β-CD complex liquid suppositories was stable, while the viscosity, gel strength and bioadhesion of MSZ HP-β-CD complex liquid suppositories were increased significantly. The in vitro gel erosion was not affected by MSZ HP-β-CD complex, while the drug release was notably enhanced. The drug release and gel erosion showed a good linear relation-ship. Conclusion:MSZ HP-β-CD complex liquid suppositories show good gel temperature, viscosity, gel erosion and bioadhesion, and the in vitro release rate is faster than that of MSZ liquid suppositories.
