Radiotherapy sensitization role of curcumin in Hela cells and its possible mechanisms

VernacularTitle:姜黄素对宫颈癌Hela细胞株放疗增敏的机制研究
Author: Li ZHANG ; Shouheng DENG ; Ping CHEN ; Jiying TANG
Publication Type:Journal Article
Keywords: Curcumin/PD; Uterine cervical neoplasms/ZD/RT/ME; Tumor suppressor protein p53/ME; Proto-oncogene proteins p21 (ras)/ME; bcl-2-associated X protein/ME; Proto-oncogene proteins c-bcl-2/ME
From: Journal of Chinese Physician 2015;17(11):1680-1681,1685
CountryChina
Language:Chinese
Abstract: Objective To investigate the mechanisms of radiotherapy sensitization role of curcumin in cervical carcinoma Hela cells.Methods Western blot was used to detect expressions of p53, p21, Bax,and Bcl-2 proteins after cervical cancer Hela cells were treated.Results The expressions of p53 and p21 proteins were increased.The ratio of Bcl-2/Bax was decreased when curcumin and irradiation were applied to cells alone (P ＜ 0.05).This change were much more obvious when irradiation and curcumin were combined than either of them was used alone(P ＜0.01).Conclusions The mechanisms of curcumin enhancing radiosensitivity on Hela cells might be due to upregulation of p53, p21, and Bax proteins and downregulation of Bcl-2 protein.