The application of lentil lectin-reactive alpha-fetoprotein ratio in the differential diagnosis of primary liver cancer
10.3969/j.issn.1673-4130.2016.09.030
- VernacularTitle:甲胎蛋白异质体比率在原发性肝癌鉴别诊断中的应用
- Author:
Xiaoling ZHAO
;
Jingjing WANG
;
Qiaoyu ZHAO
;
Liangbin HUANG
- Publication Type:Journal Article
- Keywords:
alpha-fetoprotein;
primary liver cancer;
benign liver disease;
differential diagnosis
- From:
International Journal of Laboratory Medicine
2016;37(9):1228-1229,1231
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the application of lentil lectin‐reactive alpha‐fetoprotein ratio (AFP‐L3% ) applied in the dif‐ferential diagnosis between hepatitis B infection of primary liver cancer and benign liver disease .Methods We included 108 cases of chronic HBV infection ,including 50 cases of primary liver cancer ,42 cases of cirrhosis ,16 cases of chronic hepatitis .Chemilumines‐cence detection was used to detect alpha‐fetoprotein (AFP) and AFP‐L3 content ,AFP‐L3 and the ratio of AFP (AFP‐L3% ) was calculated .Results AFP≥400 ng/mL as primary liver cancer diagnostic threshold ,the sensitivity and specificity were 36% ,84% , when used AFP‐L3% ≥ 10% as primary liver cancer diagnostic threshold ,the sensitivity and specificity were 62% ,83% . Conclusion AFP‐L3% is a better clinical indicator to distinguish between primary liver cancer and benign liver disease .AFP‐L3%can be used as a clinical indicator to differential diagnosis between HBV infection of primary liver cancer and benign liver disease .
