Expression of endoplasmic reticulum chaperone GRP78 in breast cancer and its prognosis significance
10.3760/cma.j.issn.1673-4203.2016.03.005
- VernacularTitle:内质网分子伴侣GRP78在乳腺癌中的表达及其预后意义
- Author:
Haitao GUAN
;
Zhijun DAI
;
Zhongwei WANG
;
Xiaoxu LIU
;
Xijing WANG
- Publication Type:Journal Article
- Keywords:
GRP78 protein,human;
Breast neoplasms;
Prognosis
- From:
International Journal of Surgery
2016;43(3):157-162,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of GRP78 in breast cancer,the relationships among the expression and the clinicopathological characteristics,prognosis were also investigated.Methods The expression of GRP78 was detected in 172 paraffin-embedded breast cancer samples with immunohistochemistry Envision method,the relationships among the expression and the clinicopathological characteristics,prognosis were investigated.Results Positive expression of GRP78 is common in breast cancer.Strong expression of GRP78 was detected in 71 cases (41.28％),and weak expression was detected in 101 cases (58.72％).GRP78 expression wasn't associated with the clinicopathological characterristics except T stage and Her-2 status.Univariate analysis (log-rank test) showed that GRP78 expression correlated with disease free survival and overall survival significantly.Patients with strong GRP78 expression had poorer prognosis compared to those with weak GRP78 expression(P ＜ 0.05).Multivariate analysis utilizing Cox regression analysis showed that GRP78 is an independent biomarker of disease free survival (P ＜ 0.05),but not an independent biomarker of overall survival (P ＞ 0.05).Conclusions Positive expression of GRP78 is common in breast cancer and strong expression is associated with poorer survival.
