Research on the role of MCP-1 combined with CLIF-COFs for predicting complications in patients with HBV related acute on chronic liver failure undergoing liver transplantation
10.3760/cma.j.issn.1673-4203.2015.12.003
- VernacularTitle:MCP-1结合CLIF器官衰竭评分在预测慢加急性肝衰竭患者肝移植术后并发症中的作用
- Author:
Qingliang GUO
;
Binwei DUAN
;
Shichun LU
;
Daming GAO
;
Ning LI
- Publication Type:Journal Article
- Keywords:
Cytokines;
Monocyte chemotactic protein-1;
Acute-on-chronic liver failure;
Liver transplantation
- From:
International Journal of Surgery
2015;42(12):799-803,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of cytokines combined with CLIF Consortium organ failure score (CLIF-COFs) in determining the prognosis of liver transplant in hepatitis B-related acute-on-chronic liver failure (HB-ACLF) patients.Methods Thirty-seven cases of HB-ACLF patients undergoing liver transplantation were divided into HB-ACLF patients with complications group (n =15) and those without complications (n =22).Plasma were prospectively collected immediately before LT and on the 1st,3rd,5th,7th day after LT in HB-ACLF patients.The serum levels of twenty-seven cytokines were determined by 200 LUMINEX liquid chip technology.Cytokines and CLIF-COFs were analyzed with logistic regression and the receiver operating characteristic to confirm the correlation with the total complications post-LT.Results The serum levels of post-transplant G-CSF and MCP-1 in HB-ACLF patients with complications were higher than those of without complications (P ＜ 0.05).The COX analysis indicated that MCP-1 and CLIF-COFs were predictors of post-LT complications [A UC:0.821,95％ CI:0.668-0.974;AUC:0.738,95％ CI:0.578-0.898].The discriminatory power of MCP-combined with CLIF-COFs [AUC:0.839,95％ CI:0.703-0.975] was better than that of either.Conclusions MCP-1 combined with CLIF organ failure score can better predict the short-term outcomes of liver transplantation in HB-ACLF patients.
