Effect of Wnt pathway on bone damage and bone marrow adipogenesis induced by radiochemotherapy

VernacularTitle:Wnt传导通路在肿瘤放化疗诱发骨损伤和骨髓脂肪化中的作用
Author: Xuhui XUE ; Junying WANG ; Yuanming SUN
Publication Type:Journal Article
Keywords: Wnt pathway; Radiochemotherapy; Bone damage and bone marrow fat
From: International Journal of Biomedical Engineering 2015;38(6):379-382,后插2
CountryChina
Language:Chinese
Abstract: Cancer has become the second largest life-threatening disease nowadays.Radiotherapy and chemotherapy are still important treatments for cancer.However, they tend to produce a lot of serious adverse effects including bone damage and bone marrow fat, etc.Based on recent research, the research progress on canonical Wnt pathway and its impact on stromal stem cells differentiation into osteoblasts and adipocytes are reviewed.Radiochemotherapy-induced bone damage and bone marrow fat is closely related to canonical Wnt pathway.In experimental assay and clinical application, Wnt pathway antagonists, such as Dickkopf-1 (DKK-1), sclerostin, and secreted frizzled-related protein 1 (sFRP-1) are used to relieve bone damage.Wnt pathway is expected to become a potential target for the therapy of bone damage and bone marrow fat induced by raidochemotherapy.