Correlation between epidermal growth factor receptor gene mutations and CT signs in lung adenocarcinoma
10.3760/cma.j.issn.1673-4181.2016.01.005
- VernacularTitle:肺腺癌表皮生长因子受体基因突变与CT征象的相关性
- Author:
Yanju LI
;
Zhaoxiang YE
;
Yi LI
- Publication Type:Journal Article
- Keywords:
Lung adenocarcinoma;
Epidermal growth factor receptor;
Gene mutation;
Tomography;
X-ray computed
- From:
International Journal of Biomedical Engineering
2016;39(1):20-23,31
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between epidermal growth factor receptor (EGFR) gene mutations and computed tomography (CT) characteristics in lung adenocarcinoma.Methods Chest CT scan results of 200 postoperative lung adenocarcinoma patients were retrospectively studied,the EGFR gene mutations detection results were statistically analyzed,and the correlation between EGFR gene mutations status and CT characteristics was investigated.Results Single factor analysis results showed that non smoking,female patients,air bronchogram sign and small tumor diameter were significantly associated with EGFR gene mutations (P＜0.05),and the incidence of GGO in the EGFR gene mutation group was higher than that in the wild group,but no statistical significance was found (P＞0.05),while other clinical and CT signs,such as age,lobulation,spicule,calcification,cavity and pleural indentation were not associated with EGFR gene mutations (P＞0.05).Logistics regression analysis results showed that non smoking and air bronchogram sign were significantly associated with EGFR gene mutations (P＜0.05),but gender and tumor size were not associated with EGFR gene mutations(P＞0.05).Conclusions Non smoking and air bronchogram sign may be used as predictive factors for EGFR gene mutations in lung adenocarcinoma.
