Expression of MALAT-1 gene in epithelial ovarian cancer and its clinical significance
10.3760/cma.j.issn.1006-9801.2015.11.007
- VernacularTitle:人肺腺癌转移相关转录本1基因在上皮性卵巢癌中的表达及其临床意义
- Author:
Qua HUANG
;
Li WANG
;
Hongying WANG
- Publication Type:Journal Article
- Keywords:
Ovarian neoplasms;
Long non-coding RNA;
MALAT-1
- From:
Cancer Research and Clinic
2015;27(11):745-747,759
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of the long non-coding RNA MALAT-1 in epithelial ovarian cancer (EOC).Methods The expressions of MALAT-1 mRNA in 29 EOC tissues and 20 normal ovarian tissues were detected by real-time fluorescence quantitative PCR.The relationships between the expression of MALAT-1 mRNA in EOC and its clinical pathological characteristics were analyzed.Results The expression of MALAT-1 mRNA in EOC tissues was lower than that in normal ovarian tissues (0.089±0.090 vs 1.450±1.404,t =4.331,P ＜ 0.001).The expression of MALAT-1 mRNA in advanced (Ⅲ-Ⅳ) stage tissues was significantly lower than that in early (Ⅰ-Ⅱ) stage tissues (0.044±0.043 vs 0.174±0.095,t =-5.125,P ＜ 0.05).The expression of MALAT-1 mRNA was significantly lower in poorly differentiated and poorly-moderately differentiated ovarian cancer than that in well differentiated ones (0.070 ±0.091 vs 0.161±0.021,t =2.409,P =0.023).The expression of MALAT-1 mRNA was significantly lower in tissues with the lymphonode or omental metastasis than that in tissues without invasion (0.045±0.047 vs 0.142±0.102,t =3.378,P =0.002).Conclusions The expression of long non-coding RNA MALAT-1 is lower in EOC,which is related to tumor grade,clinical stage,lymphonode and omental metastasis.It is suggested that MALAT-1 may play an inhibition role in the progress of ovarian cancer.
