Diagnostic value of bone metabolic markers for bone metastasis of non-small cell lung cancer analyzed by Logistic regression combined with ROC curve
10.3760/cma.j.issn.1006-9801.2016.03.005
- VernacularTitle:骨代谢标志物对非小细胞肺癌骨转移诊断的Logistic回归和受试者工作特征曲线评价
- Author:
Xingxi PAN
;
Wen YANG
;
Hua YANG
;
Wubing TANG
;
Yongfa CHEN
;
Yongsheng ZHANG
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small-cell lung;
Neoplasms metastasis;
β-isomerized C-terminal telopeptides of type Ⅰ collagen;
N-terminal propeptide of type Ⅰ procollage;
Logistic models;
ROC curve
- From:
Cancer Research and Clinic
2016;28(3):162-164,173
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value of bone metabolic markers (BGP, β-CTX and PINP) for bone metastasis of non-small cell lung cancer (NSCLC) analyzed by Logistic regression combined with ROC curve.Methods A total of 65 patients with stage Ⅳ NSCLC were enrolled in this study.The patients were divided into two groups based on radiological imaging, includirg bone metastasis group (30 cases) and non-bone metastasis group (35 cases).The serum concentrations of BGP, β-CTX and PINP were measured by electrochemical method.Logistic regression and ROC curve were applied to analyze the data and evaluate the diagnostic values.Results The concentrations of β-CTX [(0.54±0.39) ng/ml] and PINP [(103.64±81.86) ng/ml] were significantly higher in bone metastasis group than those [(0.31±0.16) ng/ml and (48.37±27.76) ng/ml, respectively] in non-bone metastasis group (P ＜ 0.01), while the level of BGP did not differ between two groups (P ＞ 0.05).The area under the ROC curve (AUC) for β-CTX and PINP was 0.662 and 0.678, respectively.The AUC for the new predictive variables created by Logistic regression was 0.761.Conclusion Combined detection of β-CTX and PINP in the serum and application of Logistic regression combined with ROC curve analysis can increase diagnostic accuracy on bone metastasis of NSCLC.
