Expression of p62 protein in nasopharyngeal carcinoma and its clinical significance

VernacularTitle:p62蛋白在鼻咽癌组织中的表达及临床意义
Author: Qiong WU ; Zhen CHEN ; Kun WANG ; Manlin XIANG ; Bin YI
Publication Type:Journal Article
Keywords: Proto-oncogene proteins c-myc/BI; Nasopharyngeal neoplasms/ME
From: Journal of Chinese Physician 2016;18(2):216-219,223
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between p62 expression,and occurrence and metastasis of nasopharyngeal carcinomas.Methods Immunohistochemical method was used to analyze p62 expression in 123 nasopharyngeal carcinoma (NPC) cases and 30 chronic nasopharyngitis cases.The clinical pathological characteristics were analyzed.Results The positive rate of p62 protein in chronic nasopharyngitis nasopharyngeal epithelium,non-metastatic NPC tissue,and metastatic NPC tissues was 13.3％,66.67％,and 84.72％,respectively,and the difference was statistically significant.The expression of p62 protein in nasopharyngeal carcinoma patients with lymph node metastasis or distant metastasis was significantly higher than non-metastatic NPC patients (P ＜ 0.01 or P ＜ 0.05).However,the expression of p62 was not related to age,gender,tumor size,and TNM stage (P ＞ 0.05).Conclusions High p62 protein expression in nasopharyngeal carcinoma tissue is closely related to the occurrence and metastasis of nasopharyngeal carcinomas.It provides good reference value to predict NPC malignancy and metastases.