Clinical research on COX-2 ,NF-κB and VEGF expression in triple negative breast cancer
10.3969/j.issn.1673-4130.2016.04.002
- VernacularTitle:三阴性乳腺癌中COX-2、NF-κB及VEGF表达的临床研究
- Author:
Lingdi MA
;
Yanfen DONG
;
Qian LIU
;
Jing FAN
;
Lijia JIANG
;
Yahong CHEN
- Publication Type:Journal Article
- Keywords:
triple negative breast cancer;
cyclooxygenase;
vascular endothelial growth factor
- From:
International Journal of Laboratory Medicine
2016;37(4):436-437,440
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the cyclooxygenase (COX-2) ,nuclear factor-κB (NF-κB) and vascular endothelial growth factor (VEGF) expression and clinical significance in triple negative breast cancer .Methods From January 2010 to December 2014 ,breast cancer treatment in our hospital 100 patients for the study ,50 patients with triple negative breast cancer ,50 cases of non-triple neg-ative breast cancer was detected by immunohistochemistry ,100 cases of breast cancer were detected by immunohistochemistry in or-ganizations COX-2 ,NF-κB and VEGF expression of lymphatic vessel invasion and lymph vessel density and D2-40 mark detection , statistical analysis of relevant clinical and pathological information .Results COX-2 in triple negative and non-triple negative breast cancer were 76% ,70% ,the difference was not statistically significant (P>0 .05) ,VEGF triple negative breast cancer and non-triple negative breast lesions in cancerous lesions positive expression rates of 60% and 36% ,respectively ,which had significant difference (P<0 .05) .NF-κB in triple negative breast cancer lesions and non-triple negative breast lesions positive expression rate was 66%and 32% ,respectively ,which had significant difference (P< 0 .05) .Triple negative breast cancer NF-κB and VEGF ,COX-2 and VEGF expression was significantly positively related to breast cancer .Conclusion Radiation and chemotherapy is a major means of triple negative breast cancer postoperative treatment ,while inhibiting the NF-κB ,the expression of VEGF and COX-2 is expected to become the new target for treatment of triple negative breast cancer ,is worth exploring .
