Expression and Significance of Neogenin, Hepcidin and SF in the Anemia Patients with the Tumor
10.3969/j.issn.1671-7414.2016.01.020
- VernacularTitle:肿瘤相关性贫血患者 Neogenin 的表达特点及其与 Hepcidin，SF 的关联性研究
- Author:
Yujuan SHI
;
Ye LU
;
Jinhu WANG
;
Xu CHENG
;
Xiangtao PAN
- Publication Type:Journal Article
- Keywords:
neogenin;
hepcidin;
SF;
cancer-related anemia
- From:
Journal of Modern Laboratory Medicine
2016;(1):71-72,76
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and significance of Neogenin,Hepcidin and serum ferritin(SF)in patients with cancer-related anemia.Methods To test the serum levels of Neogenin,Hepcidin and SF in 107 cases,including 55 cases with cancer-related anemia and 52 cases of non-anemia with tumor by ABC-ELISA.Results ①The serum levels of Neogenin in patients with cancer-related anemia were 0.77 ± 0.45 ng/ml,which were lower than 0.98 ± 0.60 ng/ml in non-anemia group (t=2.003 8,P <0.05).The serum levels of Hepcidin in patients with cancer-related anemia were 6.03±4.25 μg/ml, which was higher than 4.51±2.23 μg/ml in non-anemia group (t=2.319 5,P <0.05).②There were no difference in pa-tients between anemia and non-anemia (t=1.898 0,P >0.05).③In patients with cancer,there were positive correlation be-tween Neogenin and Hb (r=0.212 4,t=2.226 4,P <0.05),there were negtive correlation between Hepcidin and Hb (r=-0.310 1,t=3.345 2,P <0.01),but there were no correlation between SF and Hb (P >0.05).④There were positive cor-relation between Hepsidin and SF (r=0.486 6,P <0.01).Conclusion There were lower expression of Neogenin,higher ex-pression of Hepcidin in patients with cancer-related anemia is a complex process.The abnormal expression of Neogenin and Hepcidin which were lead to the loss of use of iron are the key factors attribute to anemia in patients with cancer.
