Influence of Seminal Plasma Reactive Oxygen Species and Cell Factors in Infertile Men with Ureaplasma Urealyticum Infection
10.3969/j.issn.1671-7414.2016.01.012
- VernacularTitle:解脲支原体感染对男性不育者精浆活性氧与细胞因子的影响
- Author:
Deqing ZHANG
;
Meng ZHANG
;
Zhongpei LI
;
Ailian YU
- Publication Type:Journal Article
- Keywords:
ureaplasma urealyticum;
male infertility;
seminal plasma;
reactive oxygen species;
cell factors
- From:
Journal of Modern Laboratory Medicine
2016;(1):44-46,51
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of seminal plasma reactive oxygen species(ROS),cell factors and sperm quality in infertile male with Uu infection and explore its action mechanism in male infertility.Methods Chose 83 cases of male in-fertility with Uu infection as the experimental group (Uu+ infertility group),30 cases of male infertility without Uu infec-tion (Uu- infertility group)and 30 normal men with children as a control (Normal fertility group).Respectively,determi-nate the levels of seminal plasma malondialdehyde (MDA),superoxide dismutase (SOD),IL-6,IL-10,IL-18 and TNF-α,and analyzed its correlation.Results In Uu+ infertility group,the levels of MDA (19.56±5.22 nmol/ml),IL-6 (58.31±8.94 pg/ml),IL-18 (38.16±17.02 pg/ml)and TNF-α(42.68±11.18 pg/ml)were obviously higher than those in the other two groups (t=4.35~20.43,P value<0.001),and the level of IL-10 (8.62±2.98 pg/ml)and SOD (95.36±20.03 μmol/L) was lower than those in the other two groups (t=3.67~23.74,P value<0.001).Correlation analysis found that MDA of Uu+ infertility group was positively correlated with TNF-α,IL-18 (r=0.61,0.55,P value<0.001),and negatively correla-ted with SOD and IL-10 (r=-0.55,-0.53,P value<0.001).Conclusion The results suggested that Uu infection caused the level of reactive oxidative increasing,cytokines counterbalance disorder and affected sperm quality.So it is of great signif-icance for the treatment to test the levels of ROS and cytokines in patients with male sterility.
