Drug-Resistance of Staphylococcus Aureus Induced by Erythromycin in Vitro
10.3969/j.issn.1671-7414.2016.01.040
- VernacularTitle:红霉素体外诱导金黄色葡萄球菌耐药分析
- Author:
Shuping NIE
;
Yang ZHANG
;
Qiong WANG
;
Lie HUANG
;
Runxiang WU
;
Lifen LING
;
Feinan FAN
- Publication Type:Journal Article
- Keywords:
staphylococcus aureus;
erythromycin;
induced-resistance
- From:
Journal of Modern Laboratory Medicine
2016;(1):138-139,143
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the drug-resistance of Staphylococcus aureus induced by erythromycin in vitro and its changes in growth and susceptibility of antibiotics.Methods Erythromycin in vitro induction was conducted with the S.au-reus reference strain ATCC25923 on the serial of erythromycin agar plates.The growth of S.aureus,and the susceptibility a-gainst other antibiotics was compared after induced to the parent strain.Results Resistance to erythromycin was successful-ly,and themaximum MIC was over 256 mg/L.The Erythromycin-resistant S.aureus grew much slower than the susceptible parent,and the strains didn’t have cross-resistance to other antibiotics.Conclusion S.aureus could be induced resistance in vitro by erythromycin,and this resistance inherited stably.Some phenotype and biochemical characteristic features of the strain were changed after induced.
