The laboratory diagnose of children hemphagocytic lymphohistiocytosis
10.3969/j.issn.1673-4130.2016.02.021
- VernacularTitle:儿童噬血细胞性淋巴组织细胞增生综合征13例实验室诊断分析
- Author:
Wei SHEN
;
Xia WU
;
Dexing LUO
;
Yongqiong WEI
;
Chenggui LIU
- Publication Type:Journal Article
- Keywords:
histiocytosis/diagnosis;
laboratory techniques and procedures;
retrospective studies;
child
- From:
International Journal of Laboratory Medicine
2016;(2):194-195,198
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the cause and the level change of laboratory indicators in children with hemphagocytic lym‐phohistiocytosis(HLH) .Methods Retrospectively analyze the cause and the diagnose features of the 13 HLH patients .Results The first symptom of the desease was hyperpyrexia as well as the hepatosplenomegaly and the lymphadenectasis .Then it went with the peripheral cytopenia in two or three lineages ,different degrees of the liver dysfunction and the coagulation abnormalities .The number of histiocytes increased and hemophagocytic macrophages were found in bone marrow .It also showed that the elevated ser‐um triglycerides ,serum ferritin ,lactate dehydrogenase and glutamic‐pyruvic transaminase and decreased fibrinogen in laboratory findings .Conclusion Cytopenia(in two or three lineages ,especially the platelet) ,the elevated serum triglycerides ,serum ferritin , lactate dehydrogenase ,glutamic‐pyruvic transaminase ,decreased fibrinogen and the hemophagocytic macrophages in bone marrow (≥1% ) are important indicators in hemphagocytic lymphohistiocytosis diagnosis ,which could help us know the change of the HLH laboratory features better and diagnose the disease correctly .
