Correlation between prognosis and expression of EGFR, HER2 and HER3 in non-small cell lung cancer
10.3760/cma.j.issn.1006-9801.2016.02.001
- VernacularTitle:表皮生长因子受体、人类表皮生长因子受体2、人类表皮生长因子受体3表达与非小细胞肺癌预后的关系
- Author:
Kunning ZHANG
;
Jun LU
;
Hongying ZHAO
;
Mulan JIN
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small-cell lung;
Receptor,epidermal growth factor;
Human epidermal growth factor receptor-2;
Human epidermal growth factor receptor-3;
Prognosis
- From:
Cancer Research and Clinic
2016;28(2):73-77,89
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the clinical pathological factors and the expression of EGFR, HER2 and HER3 in non-small cell lung cancer tissues. Methods The expression of EGFR, HER2 and HER3 in non-small cell lung cancer tissues was detected by MaxVision immunohistochemical. The relationship between the protein expression and the clinical pathologic characteristics was studied. The correlation between the protein expression and the survival was also retrospectively analyzed. Results Increased expression of EGFR, HER2 and HER3 was detected in the NSCLC tissues and their rates were 45.9 % (73/156), 30.8 % (49/156) and 21.4 % (37/156), respectively. There were significant associations between the expression of these proteins and lymph node metastasis, tumor differentiation degree and TNM staging. Conclusions Overexpression of EGFR, HER2, HER3 or all three proteins is a predictor of poor prognosis. Moreover, combined detection of all 3 markers may work better than the individual detection in the prediction of the prognosis to guide the clinical treatment.
