Efficacy observation of hemocoagulase for the treatment of severe hemorrhagic cystitis following allogeneic hematopoietic stem cell transplantation

VernacularTitle:蛇毒血凝酶治疗异基因造血干细胞移植后重度出血性膀胱炎效果观察
Author: Feng DU ; Shengli XUE ; Wei GONG ; Tao TAO ; Yishun TAN ; Jing XU ; Chunmei YE ; Feng CHEN ; Depei WU
Publication Type:Journal Article
Keywords: Hemorrhagic cystitis; Hemotopoietic stem cell transplantation; Hemocoagulase
From: Journal of Leukemia & Lymphoma 2016;25(2):106-110,115
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical efficacy of hemocoagulase for severe hemorrhagic cystitis (HC) following allogeneic hemotopoietic stem cell transplantation (HSCT). Methods Twenty patients undergoing allogeneic HSCT developed severe HC with an onset time of 14 to 70 days, all patients received the treatment of hemocoagulase (1 U ivgtt q12 h × 5 d). The urine speciments reserved before and after hemocoagulase were examined by naked eye and microscope to evaluate the efficacy. Results Twenty patients received the treatment of hemocoagulase. The HC was cured in 18 patients, improved in 1 patient and uncontrolled in 1 patient. For the patients with response, macroscopic hematuria disappeared at a median of 28 days (4-127 days) after the treatment. All procedures were tolerated well and no severe adverse effect was observed. Conclusion Hemocoagulase seems to be a safe and effective drug for severe HC following HSCT.